Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025. SignificanceNav1.8 sodium channels are highly expressed in primary pain-sensing neurons. Suzetrigine is a potent and highly selective Nav1.8 inhibitor that has recently been approved by the Food and Drug Administration for treating acute pain. We find …
Observations from the Little Bunker
Last updated: October 16, 2025 02:57 AM
Atmospheric COâ‚‚
424.4 ppm
+18.2
ppm/year
Atmospheric CHâ‚„
1933.54 ppb
+12.29
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year