Proceedings of the National Academy of Sciences, Volume 122, Issue 26, July 2025. SignificanceMetabolic reprogramming is a notable phenotype during the acquisition of resistance to chemotherapy drugs. Thus, reverting metabolism can be an effective strategy to sensitize drug-resistant cells. The computational framework developed in this …
Observations from the Little Bunker
Last updated: August 18, 2025 04:13 PM
Atmospheric CO₂
425.4 ppm
+18.4
ppm/year
Atmospheric CH₄
1934.91 ppb
+9.11
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year