Proceedings of the National Academy of Sciences, Volume 122, Issue 35, September 2025. SignificanceMutations in the protein tyrosine phosphatase SHP2 that cause Noonan syndrome with multiple lentigines (NSML) result in the development of RASopathy-associated hypertrophic cardiomyopathy (HCM). This study shows that in the heart, when SHP2 …
Observations from the Little Bunker
Last updated: October 16, 2025 04:11 AM
Atmospheric CO₂
424.4 ppm
+18.2
ppm/year
Atmospheric CH₄
1933.54 ppb
+12.29
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year