Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025. SignificanceThis study reveals the structural basis for allosteric modulation of SV2A, a key synaptic vesicle protein and target for epilepsy. Structures of the SV2A-BRV-UCB1244283, -UCB-J, and -UCB7361 complexes show that simultaneous binding of certain …
Observations from the Little Bunker
Last updated: October 16, 2025 04:11 AM
Atmospheric COâ‚‚
424.4 ppm
+18.2
ppm/year
Atmospheric CHâ‚„
1933.54 ppb
+12.29
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year