Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025. SignificanceMycobacterium tuberculosis(Mtb) is the leading cause of death by an infectious agent. The frontline antibiotic isoniazid (INH), which inhibits mycolic acid biosynthesis inMtb, is at the cornerstone of all current regimens to treat drug-…
Observations from the Little Bunker
Last updated: October 16, 2025 04:11 AM
Atmospheric COâ‚‚
424.4 ppm
+18.2
ppm/year
Atmospheric CHâ‚„
1933.54 ppb
+12.29
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year