Proceedings of the National Academy of Sciences, Volume 122, Issue 37, September 2025. The 2025 Lasker~DeBakey Clinical Medical Research Award has been given to Michael Welsh, JesĂşs (Tito) GonzĂĄlez, and Paul Negulescu for their key roles in developing a novel treatment for cystic fibrosis (CF)âa three-drug combination that saves the lives âŚ