Proceedings of the National Academy of Sciences, Volume 122, Issue 38, September 2025. SignificanceGBM patients face extremely limited treatment options and poor responses to current immunotherapies. Our findings reveal that targeting the Wnt7b/β-catenin pathway can sensitize stem-cell rich GBM to immune checkpoint blockade, offering a …
Observations from the Little Bunker
Last updated: October 16, 2025 04:11 AM
Atmospheric CO₂
424.4 ppm
+18.2
ppm/year
Atmospheric CH₄
1933.54 ppb
+12.29
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year