Proceedings of the National Academy of Sciences, Volume 122, Issue 44, November 2025. Significanceβ-amyloid (Aβ)-degrading enzymes (ADEs) promote Aβ-clearance and counteract amyloidosis. Insufficient cerebral Aβ clearance has been demonstrated as an early and central pathophysiological alteration within the AD biological continuum. The …
Observations from the Little Bunker
Last updated: November 30, 2025 04:25 AM
Atmospheric CO₂
426.8 ppm
+18.1
ppm/year
Atmospheric CH₄
1927.61 ppb
+2.73
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year