Abstract Future changes in El Niño‐Southern Oscillation (ENSO), the dominant mode of global climate variability, remain uncertain. Accordingly, large ensembles—which allow internally‐generated variations to be averaged out—are essential for assessing the response of ENSO to external forcing. In this study, we analyze state‐of‐the‐art large‐ensemble simulations from CMIP6 climate models and show that, in most models, ENSO frequency increases under anthropogenic warming. Two factors drive this frequency increase. First, a shift toward the Eastern Pacific (EP) El Niño pattern—characterized by higher frequencies and greater amplitudes relative to the Central Pacific (CP) pattern. Second, an overall increase in the frequency of both EP and CP variability. These changes scale with the intensity of anthropogenic forcing. Most models also exhibit ENSO strengthening that begins in the 20th $20\text{th}$ century and continues throughout the 21st $21\text{st}$ century. Consequently, the observed intensification of ENSO during the second half of the 20th $20\text{th}$ century could be of anthropogenic origin.