Proceedings of the National Academy of Sciences, Volume 122, Issue 45, November 2025. SignificanceLipid nanoparticles deliver mRNA to the liver in people, but delivery to other tissues is challenging. Liver detargeting is important because it increases the availability of drug to deliver to other organs (e.g., the spleen). To produce lipid …
Observations from the Little Bunker
Last updated: November 30, 2025 04:25 AM
Atmospheric CO₂
426.8 ppm
+18.1
ppm/year
Atmospheric CH₄
1927.61 ppb
+2.73
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year