Nature Climate Change, Published online: 24 November 2025; doi:10.1038/s41558-025-02507-7Interactions between climate change and antimicrobial resistance across terrestrial, aquatic and health systems reveal shared drivers, synergies and trade-offs that shape health and environmental outcomes. This Comment outlines a solutions-oriented research agenda to advance evidence and action that addresses climate change and antimicrobial resistance as interconnected issues.