Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. SignificanceThis study reveals how a modified form of amyloid-beta (Aβ) disrupts mitochondrial function in neurons, triggering innate immunity and disease progression. We show that this modified Aβ damages mitochondria, activating a specific immune …
Observations from the Little Bunker
Last updated: November 29, 2025 10:10 AM
Atmospheric CO₂
426.6 ppm
+18.0
ppm/year
Atmospheric CH₄
1927.61 ppb
+2.73
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year