Proceedings of the National Academy of Sciences, Volume 122, Issue 52, December 2025. SignificanceAtaxia-telangiectasia (A-T) is a pleiotropic genetic disorder caused by mutations in theATMgene. Its gene product, ATM kinase, is canonically involved in regulating DNA damage responses. Herein, we describe how ATM regulates the …
Observations from the Little Bunker
Last updated: December 31, 2025 02:11 PM
Atmospheric CO₂
427.9 ppm
+18.1
ppm/year
Atmospheric CH₄
1930.95 ppb
+-3.5
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year