Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. SignificanceThis study reveals how ESCC cells manipulate TAMs to promote tumor progression. We found that tumor-secreted cholesterol triggers a molecular network in macrophages (TFEB-PLD3-TLR9 axis), suppressing their ability to activate antitumor T …
Observations from the Little Bunker
Last updated: January 27, 2026 08:12 PM
Atmospheric CO₂
428.6 ppm
+17.4
ppm/year
Atmospheric CH₄
1940.59 ppb
+-0.24
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year