Proceedings of the National Academy of Sciences, Volume 123, Issue 13, March 2026. SignificanceInfluenza remains a major global health threat. We introduce oseltamivir-based aziridines that unite transition-state mimicry for tight binding with aziridine-enabled covalent capture of the catalytic tyrosine. This dual function yields potent,…
Observations from the Little Bunker
Last updated: April 07, 2026 10:27 PM
Atmospheric CO₂
431.7 ppm
+18.3
ppm/year
Atmospheric CH₄
1945.85 ppb
+8.44
ppb/year
Global Temperature
+1.48 °C
Peak: +1.73°C
World Population
8.1 billion
+67
million/year