Proceedings of the National Academy of Sciences, Volume 123, Issue 23, June 2026. SignificanceIn peripheral tissues, lipoprotein lipase (LPL) is synthesized by adipocytes and myocytes, secreted into the interstitial spaces, and then captured by GPIHBP1 on capillary endothelial cells. The LPL inside capillaries hydrolyzes triglycerides β¦