Abstract We investigate the North Atlantic (NA) tropical cyclone (TC) response to a substantial weakened Atlantic Meridional Overturning Circulation (AMOC) under external freshwater forcing using a high‐resolution coupled model. With explicit TC trackings instead of indirect inferences from large‐scale environmental changes, we detect a non‐uniform AMOC‐linked NA TC reduction. The transient TC reduction is more rapid and pronounced over the eastern NA. After several decades, the TCs are almost absent over the eastern NA and the remaining substantially reduced TCs are mostly confined over the western subtropical NA. This non‐uniform TC reduction is related to the equatorward propagation of negative extratropical surface temperature and near‐surface humidity anomalies along a horseshoe pathway as the AMOC weakens. Concurrently, vertical wind shear strengthens over the tropical NA, reinforcing the TC suppression there. In contrast, the AMOC weakening induces TC‐favorable environmental changes (e.g., surface warming) and thus the emergence of TCs over the South Atlantic.