Abstract The total electron content observations during the Artemis‐II Lunar mission revealed rare ionospheric perturbations occurring at three different occasions. The launch at 2235 UT on 1 April 2026 from Kennedy Space Center induced shock‐acoustic and gravity wave modulations. Subsequent Apogee Raise Maneuver (ARM) performed at 0023 UT on 2 April triggered shock waves and much intense large‐scale disturbances that elongated ∼50° longitude across North America. The third orbital maneuver conducted as part of trans‐Lunar injection (TLI) at 2349 UT on 2 April, yielded similar, but weaker large‐scale perturbations. This is the first time a single space mission producing such multiple ionospheric disturbances over the same region. The observed amplitudes suggest that despite releasing large exhaust energy, the disturbances during the rocket ascent produced weaker perturbations, whereas fewer amounts of direct energy deposition at ionosphere altitudes during ARM and TLI yielded up to 9 times intense perturbations elongated along the trajectory.