Observations from the Little Bunker

As sea levels climb and weather grows more extreme, coastal regions everywhere are facing a creeping threat: salt. Salinization of freshwater and soils adversely affects 500 million people around the...

Mosquito experts say cuts in aid will lead to collapse of crucial surveillance and control in endemic countriesClimate change could make the UK vulnerable to insect-transmitted tropical diseases that were...

Abstract Non–small cell lung cancer (NSCLC) constitutes over 80% of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Despite the advent of immune checkpoint inhibitors, their...

Abstract The adult mammalian heart has limited regenerative capacity due to the low proliferative ability of cardiomyocytes, whereas embryonic cardiomyocytes exhibit robust proliferative potential. Using single-cell RNA sequencing of embryonic...

Abstract Lysine-specific histone demethylase 1A (LSD1) is an epigenetic regulator involved in various biological processes, including metabolic pathways. We demonstrated the therapeutic potential of its pharmacological inhibition in glioblastoma using...

Abstract Chronic stress exposure is a primary contributor to the development of anxiety disorders, closely associated with hippocampal dysfunction. However, the underlying molecular mechanism remains poorly understood. Here, using a...

Abstract β-Site amyloid precursor protein (APP)–cleaving enzyme 1 (BACE1) is the rate-limiting enzyme for amyloid-β (Aβ) generation and is considered promising drug target for Alzheimer’s disease (AD). The co-chaperone BAG3...

Abstract Action sequencing is fundamental to behavior. A critical decision for survival and reproduction is whether to repeat a current action or switch to a different one. However, the neural...

Abstract Microbial responses to environmental changes are well studied in laboratory cultures, but in situ adaptations of plankton lipidomes remain less understood. Building upon a global lipidomic study showing temperature-driven...

Abstract The development of the airway epithelium in asthma is unclear. We characterized nasal airway epithelial cell (NAEC) developmental phenotypes from children aged 2 to 3 years in an a...

Abstract Spacecraft magnetometry and paleomagnetic measurements of lunar samples provide evidence that the Moon had a magnetic field billions of years ago. Because this field was likely stronger than that...

Abstract Major depression is a prevalent and devastating psychiatric disorder. However, our understanding of the underlying molecular mechanisms is limited. Here, we found reduced expression of zinc finger protein with...

Abstract AMBRA1 is a tumor suppressor protein that functions as a substrate receptor in the ubiquitin conjugation system and regulates the stability of D-type cyclins and cell proliferation. Here, we...

Abstract Broadband photodetection, especially for the high-intensity pulsed lasers, has garnered increasing interest in photophysics and applied sciences driven by the development of pulsed lasers. However, direct broadband photodetection of...

Abstract Tremendous efforts have been dedicated to facilitating heat dissipation into cold universe through radiative cooling. Nevertheless, its applications remain limited by overcooling in cold conditions and reduced effectiveness under...

Abstract Vanadium oxides (VOs) are promising cathode materials for aqueous batteries due to their high theoretical capacity, but they face challenges such as sluggish kinetics and V dissolution. To overcome...

Abstract Traditional dynamic random access memory (DRAM) technology faces grand challenges in power consumption due to the constant data refresh and in density due to the physical limit for dimension...

Common land organizations and institutions (hereinafter: CLOIs) have been extensively studied worldwide. However, the extent of the European ones is relatively unknown, despite studies and evidence of their long existence....

Greenhouse gas emissions from burning fossil fuels are routinely counted in energy and climate policies, yet the immediate health burden of air pollution emissions from combusting these fuels is rarely...

Severe pre-monsoonal heat stress has become a routine occurrence in several tropical regions. Motivated by the surmounting evidence that high ambient humidity worsens the perception of heat during these events,...

Commensuration of the radiative effects of different greenhouse gases (GHGs) is crucial for understanding the effects of land cover and ecosystem changes on the global climate. However, none of the...

The Brazilian diplomats presiding over the COP30 climate summit in November have said they want an “early harvest” at June’s mid-year climate negotiations in Bonn, aiming to secure agreements on...

Abstract (Titano)magnetite is the major magnetic carrier in igneous rocks, whether it can decode the influence of subduction fluids and fractional crystallization characteristics in back‐arc basins is unclear. Here, we...

Abstract Substorms are known to induce global magnetosphere‐ionosphere coupling. However, the specific response of the dayside ionospheric electric field and its influence on the equatorial electrojet (EEJ) remain controversial. This...